InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krt20

Summary

InnateDB Protein

IDBP-211050.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt20

Protein Name

keratin 20

Synonyms

9030623C06Rik; CK20; K20; KRT21;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017743

InnateDB Gene

IDBG-211048 (Krt20)

Protein Structure

UniProt Annotation

Function

Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine. {ECO:0000269PubMed:12857878, ECO:0000269PubMed:16608857}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed at low levels in the more differentiated suprabasal regions of the small intestine, and at higher levels in the colon, mainly in the upper region and in scattered cells throughout the remaining epithelium. Also expressed in epithelial cells of bladder, ileum and stomach and at lower levels in pancreas and earskin. The phosphorylated form is nearly exclusively expressed in goblet cells of the small intestine and in the lumen-proximal cells of the colon (at protein level). Also expressed in jejunum and duodenum. {ECO:0000269PubMed:12857878, ECO:0000269PubMed:16608857}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0033554	cellular response to stress
GO:0045109	intermediate filament organization
GO:0050708	regulation of protein secretion

Cellular Component

GO:0005737	cytoplasm
GO:0005882	intermediate filament

Protein Structure and Domains

PDB ID

MGI:1914059

InterPro

IPR001664 Intermediate filament protein
IPR002957 Keratin, type I

PFAM

PF00038

PRINTS

PR01248

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D312

PhosphoSite

PhosphoSite-Q9D312

TrEMBL

UniProt Splice Variant

Entrez Gene

66809

UniGene

Mm.28042

RefSeq

NP_075745

MGI ID

MGI Symbol

Krt20

OMIM

CCDS

CCDS25381

HPRD

IMGT

EMBL

AF473907 AK018567 AL591165 BC057172

GenPept

AAH57172 AAL82480 BAB31280 CAM21365