InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chst15

Summary

InnateDB Protein

IDBP-211058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chst15

Protein Name

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

Synonyms

4631426J05Rik; BRAG; GalNAcS-6ST; MAd5; mKIAA0598;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079105

InnateDB Gene

IDBG-211054 (Chst15)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity