InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krt14

Summary

InnateDB Protein

IDBP-211286.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt14

Protein Name

keratin 14

Synonyms

AI626930; K14; Krt-1.14; Krt1-14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007272

InnateDB Gene

IDBG-211284 (Krt14)

Protein Structure

UniProt Annotation

Function

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expressed in both as a filamentous pattern. {ECO:0000250}.

Disease Associations

Tissue Specificity

Basal cells of epidermis and other stratified epithelia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:1990254	keratin filament binding

Biological Process

GO:0007568	aging
GO:0010043	response to zinc ion
GO:0010212	response to ionizing radiation
GO:0030855	epithelial cell differentiation
GO:0042633	hair cycle
GO:0045110	intermediate filament bundle assembly

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0045095	keratin filament
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery