Version 5.4
Mus musculus Protein: Gast
Summary
InnateDB Protein IDBP-211333.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gast
Protein Name gastrin
Synonyms GAS;
Species Mus musculus
Ensembl Protein ENSMUSP00000017309
InnateDB Gene IDBG-211331 (Gast)
Protein Structure
UniProt Annotation
Function Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas. {ECO:0000269PubMed:8647266}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:104768
InterPro IPR001651 Gastrin/cholecystokinin peptide hormone
PFAM PF00918
PRINTS
PIRSF
SMART SM00029
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48757
PhosphoSite PhosphoSite-
TrEMBL Q9CTZ2
UniProt Splice Variant
Entrez Gene 14459
UniGene Mm.4767
RefSeq NP_034387
MGI ID
MGI Symbol Gast
OMIM
CCDS CCDS25418
HPRD
IMGT
EMBL AK008062 AK008159 AK008313 AK008420 AK008494 AK008649 AK019058 AL590968 U34293 U58136 X94758 X94760
GenPept AAB06947 AAB97872 BAB25437 BAB25501 BAB25596 BAB25658 BAB25699 BAB25807 BAB31528 CAA64385 CAA64386 CAM23027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca