InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgm2

Summary

InnateDB Protein

IDBP-211419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgm2

Protein Name

transglutaminase 2, C polypeptide

Synonyms

G[a]h; TG2; TGase2; tTG; tTGas;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099411

InnateDB Gene

IDBG-211417 (Tgm2)

Protein Structure

UniProt Annotation

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003810	protein-glutamine gamma-glutamyltransferase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008483	transaminase activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0018149	peptide cross-linking
GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277	apoptotic cell clearance
GO:0045785	positive regulation of cell adhesion
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050729	positive regulation of inflammatory response
GO:0051260	protein homooligomerization
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060662	salivary gland cavitation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome