InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kndc1

Summary

InnateDB Protein

IDBP-211574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kndc1

Protein Name

kinase non-catalytic C-lobe domain (KIND) containing 1

Synonyms

2410012C07Rik; B830014K08Rik; very-kind; VKIND;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050586

InnateDB Gene

IDBG-211572 (Kndc1)

Protein Structure

UniProt Annotation

Function

Probable guanine nucleotide exchange factor (GEF).

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in the brain and at low levels in the ovary. In the brain it is most prominently expressed in the cerebellum where it is restricted to the granular Purkinje cell layer. {ECO:0000269PubMed:16099729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007264	small GTPase mediated signal transduction
GO:0021707	cerebellar granule cell differentiation
GO:0032318	regulation of Ras GTPase activity
GO:0048814	regulation of dendrite morphogenesis
GO:0050773	regulation of dendrite development
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0030425	dendrite
GO:0032045	guanyl-nucleotide exchange factor complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1923734

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR011009 Protein kinase-like domain
IPR011019 KIND
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147
SM00750

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0KK55