InnateDB Protein
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IDBP-211996.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Vps25
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Protein Name
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vacuolar protein sorting 25 (yeast)
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Synonyms
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1110020N13Rik; AW107467; D11Wsu68e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000007533
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InnateDB Gene
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IDBG-267009 (Vps25)
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Protein Structure
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Function |
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106354
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InterPro |
IPR008570
ESCRT-II complex, vps25 subunit
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PFAM |
PF05871
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CQ80
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
28084
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UniGene |
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RefSeq |
NP_001271343
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MGI ID |
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MGI Symbol |
Vps25
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OMIM |
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CCDS |
CCDS70312
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HPRD |
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IMGT |
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EMBL |
AK002500
AK003715
AK003877
AK145811
AK150822
AK166008
AL590969
BC029181
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GenPept |
AAH29181
BAB22148
BAB22955
BAB23054
BAE26665
BAE29884
BAE38516
CAM19564
CAM19566
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