InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbpjl

Summary

InnateDB Protein

IDBP-212140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbpjl

Protein Name

recombination signal binding protein for immunoglobulin kappa J region-like

Synonyms

RBP-L; Rbpsuhl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017151

InnateDB Gene

IDBG-212138 (Rbpjl)

Protein Structure

UniProt Annotation

Function

Putative transcription factor, which cooperates with EBNA2 to activate transcription.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9111338}.

Disease Associations

Tissue Specificity

Highly expressed in lung. Also detected in spleen, and brain. {ECO:0000269PubMed:9111338}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:1196616

InterPro

IPR002909 IPT domain
IPR008967 p53-like transcription factor, DNA-binding
IPR014756 Immunoglobulin E-set
IPR015350 Beta-trefoil DNA-binding domain
IPR015351 LAG1, DNA binding

PFAM

PF01833
PF09270
PF09271

PRINTS

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08674