Version 5.4
Mus musculus Protein: Zfp335
Summary
InnateDB Protein IDBP-212442.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp335
Protein Name zinc finger protein 335
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038298
InnateDB Gene IDBG-212440 (Zfp335)
Protein Structure
UniProt Annotation
Function Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. {ECO:0000269PubMed:23178126}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23178126}.
Disease Associations
Tissue Specificity Expressed at low levels in cerebral cortex, hippocampus and cerebellum (at protein level). {ECO:0000269PubMed:23178126}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002052 positive regulation of neuroblast proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0010468 regulation of gene expression
GO:0021895 cerebral cortex neuron differentiation
GO:0040029 regulation of gene expression, epigenetic
GO:0048812 neuron projection morphogenesis
GO:0048854 brain morphogenesis
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050767 regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0051569 regulation of histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
Cellular Component
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
Protein Structure and Domains
PDB ID MGI:2682313
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2A5K6
PhosphoSite PhosphoSite-A2A5K6
TrEMBL Q8C1Q2
UniProt Splice Variant
Entrez Gene 329559
UniGene Mm.330776
RefSeq NP_950192
MGI ID
MGI Symbol Zfp335
OMIM
CCDS CCDS38331
HPRD
IMGT
EMBL AK007785 AK157577 AL591495 BC151013 BC157954
GenPept AAI51014 AAI57955 BAC25187 BAE34126 CAM26462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca