InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc4a1

Summary

InnateDB Protein

IDBP-212592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a1

Protein Name

solute carrier family 4 (anion exchanger), member 1

Synonyms

Ae1; CD233; Empb3; l11Jus51;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006749

InnateDB Gene

IDBG-212590 (Slc4a1)

Protein Structure

UniProt Annotation

Function

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney. {ECO:0000250}.

Disease Associations

Tissue Specificity

Erythrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008509	anion transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0030506	ankyrin binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006810	transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0015701	bicarbonate transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:109393

InterPro

IPR001717 Anion exchange protein
IPR002977 Anion exchange protein 1
IPR003020 Bicarbonate transporter, eukaryotic
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00955
PF07565

PRINTS

PR00165
PR01187
PR01231

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04919