InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phlda2

Summary

InnateDB Protein

IDBP-212751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phlda2

Protein Name

pleckstrin homology-like domain, family A, member 2

Synonyms

Ipl; Tssc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010904

InnateDB Gene

IDBG-212749 (Phlda2)

Protein Structure

UniProt Annotation

Function

Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids. {ECO:0000269PubMed:12032310}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12374806}. Membrane {ECO:0000269PubMed:12374806}; Peripheral membrane protein {ECO:0000269PubMed:12374806}.

Disease Associations

Tissue Specificity

Specifically expressed at high levels in extraembryonic tissues in the developing conceptus (at protein level). Expressed in placenta and yolc sac. Expressed at low levels in fetal liver and kidney. {ECO:0000269PubMed:10594239}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001890	placenta development
GO:0009887	organ morphogenesis
GO:0010468	regulation of gene expression
GO:0030334	regulation of cell migration
GO:0045995	regulation of embryonic development
GO:0070873	regulation of glycogen metabolic process