InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gfap

Summary

InnateDB Protein

IDBP-212844.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gfap

Protein Name

glial fibrillary acidic protein

Synonyms

AI836096;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077061

InnateDB Gene

IDBG-212840 (Gfap)

Protein Structure

UniProt Annotation

Function

GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Associated with intermediate filaments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain; isoform 2 expressed at 20-fold lower level than isoform 1. {ECO:0000269PubMed:12058025}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0009611	response to wounding
GO:0010625	positive regulation of Schwann cell proliferation
GO:0010977	negative regulation of neuron projection development
GO:0014002	astrocyte development
GO:0030198	extracellular matrix organization
GO:0031102	neuron projection regeneration
GO:0045103	intermediate filament-based process
GO:0045109	intermediate filament organization
GO:0051580	regulation of neurotransmitter uptake
GO:0060020	Bergmann glial cell differentiation
GO:0060291	long-term synaptic potentiation