InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgis

Summary

InnateDB Protein

IDBP-213026.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ptgis

Protein Name

prostaglandin I2 (prostacyclin) synthase

Synonyms

Cyp8; Cyp8a1; Pgis;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085357

InnateDB Gene

IDBG-213024 (Ptgis)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008116	prostaglandin-I synthase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0042981	regulation of apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:1097156

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9ESQ6

UniProt Splice Variant

Entrez Gene

19223

UniGene

RefSeq

MGI ID

MGI Symbol

Ptgis

OMIM

CCDS

HPRD

IMGT

EMBL

AB040750 AK048059 AL591854 AY285779 CH466551

GenPept

AAP37445 BAB12574 BAC33227 EDL06503