InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgis

Summary

InnateDB Protein

IDBP-213028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgis

Protein Name

prostaglandin I2 (prostacyclin) synthase

Synonyms

Cyp8; Cyp8a1; Pgis;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018113

InnateDB Gene

IDBG-213024 (Ptgis)

Protein Structure

UniProt Annotation

Function

Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008116	prostaglandin-I synthase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0050728	negative regulation of inflammatory response
GO:0055114	oxidation-reduction process
GO:0071347	cellular response to interleukin-1
GO:0071354	cellular response to interleukin-6
GO:0071456	cellular response to hypoxia
GO:0097190	apoptotic signaling pathway
GO:1900119	positive regulation of execution phase of apoptosis

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005901	caveola
GO:0016021	integral component of membrane