InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pck1

Summary

InnateDB Protein

IDBP-213368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pck1

Protein Name

phosphoenolpyruvate carboxykinase 1, cytosolic

Synonyms

AI265463; Pck-1; PEPCK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029017

InnateDB Gene

IDBG-213366 (Pck1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004611	phosphoenolpyruvate carboxykinase activity
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525	GTP binding
GO:0017076	purine nucleotide binding
GO:0019003	GDP binding
GO:0030145	manganese ion binding
GO:0031406	carboxylic acid binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006107	oxaloacetate metabolic process
GO:0006475	internal protein amino acid acetylation
GO:0006629	lipid metabolic process
GO:0014823	response to activity
GO:0032868	response to insulin
GO:0042593	glucose homeostasis
GO:0046327	glycerol biosynthetic process from pyruvate