InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkca

Summary

InnateDB Protein

IDBP-213738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkca

Protein Name

protein kinase C, alpha

Synonyms

AI875142; Pkca;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062392

InnateDB Gene

IDBG-213736 (Prkca)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004698	calcium-dependent protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0035403	histone kinase activity (H3-T6 specific)

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002026	regulation of the force of heart contraction
GO:0002062	chondrocyte differentiation
GO:0002159	desmosome assembly
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0008285	negative regulation of cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0030335	positive regulation of cell migration
GO:0030593	neutrophil chemotaxis
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035408	histone H3-T6 phosphorylation
GO:0035556	intracellular signal transduction
GO:0036289	peptidyl-serine autophosphorylation
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045931	positive regulation of mitotic cell cycle
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050729	positive regulation of inflammatory response
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050930	induction of positive chemotaxis
GO:0070555	response to interleukin-1
GO:0071322	cellular response to carbohydrate stimulus
GO:0090330	regulation of platelet aggregation
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97595

InterPro

IPR000008 C2 domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014375 Protein kinase C, alpha/beta/gamma types
IPR017892 Protein kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00168
PF00069
PF07714
PF00130
PF00433

PRINTS

PR00360
PR00109
PR00008

PIRSF

PIRSF000550

SMART

SM00239
SM00133
SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References