InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkar1a

Summary

InnateDB Protein

IDBP-213858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkar1a

Protein Name

protein kinase, cAMP dependent regulatory, type I, alpha

Synonyms

1300018C22Rik; RIalpha; Tse-1; Tse1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056500

InnateDB Gene

IDBG-213854 (Prkar1a)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005515	protein binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0034236	protein kinase A catalytic subunit binding

Biological Process

GO:0001707	mesoderm formation
GO:0001932	regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007143	female meiotic division
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0045214	sarcomere organization
GO:0045835	negative regulation of meiosis
GO:0045859	regulation of protein kinase activity
GO:0060038	cardiac muscle cell proliferation
GO:2000480	negative regulation of cAMP-dependent protein kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0016020	membrane
GO:0031588	AMP-activated protein kinase complex
GO:0031594	neuromuscular junction
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:104878

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012198 cAMP-dependent protein kinase regulatory subunit
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF02197

PRINTS

PR00103

PIRSF

PIRSF000548

SMART

SM00100
SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References