InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox9

Summary

InnateDB Protein

IDBP-213998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox9

Protein Name

SRY-box containing gene 9

Synonyms

2010306G03Rik; AV220920; mKIAA4243;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000579

InnateDB Gene

IDBG-213996 (Sox9)

Protein Structure

UniProt Annotation

Function

Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	9 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0034236	protein kinase A catalytic subunit binding
GO:0035326	enhancer binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0097157	pre-mRNA intronic binding

Biological Process

GO:0001501	skeletal system development
GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001708	cell fate specification
GO:0001837	epithelial to mesenchymal transition
GO:0001894	tissue homeostasis
GO:0001934	positive regulation of protein phosphorylation
GO:0001942	hair follicle development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0002063	chondrocyte development
GO:0002683	negative regulation of immune system process
GO:0003170	heart valve development
GO:0003179	heart valve morphogenesis
GO:0003188	heart valve formation
GO:0003203	endocardial cushion morphogenesis
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0003415	chondrocyte hypertrophy
GO:0006334	nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006468	protein phosphorylation
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007283	spermatogenesis
GO:0007417	central nervous system development
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010564	regulation of cell cycle process
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0014032	neural crest cell development
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016337	single organismal cell-cell adhesion
GO:0019100	male germ-line sex determination
GO:0019933	cAMP-mediated signaling
GO:0030154	cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030238	male sex determination
GO:0030279	negative regulation of ossification
GO:0030502	negative regulation of bone mineralization
GO:0030850	prostate gland development
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030858	positive regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0030903	notochord development
GO:0030916	otic vesicle formation
GO:0031018	endocrine pancreas development
GO:0032331	negative regulation of chondrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035019	somatic stem cell maintenance
GO:0035622	intrahepatic bile duct development
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043491	protein kinase B signaling
GO:0045165	cell fate commitment
GO:0045595	regulation of cell differentiation
GO:0045662	negative regulation of myoblast differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046533	negative regulation of photoreceptor cell differentiation
GO:0048709	oligodendrocyte differentiation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0060008	Sertoli cell differentiation
GO:0060009	Sertoli cell development
GO:0060018	astrocyte fate commitment
GO:0060041	retina development in camera-type eye
GO:0060174	limb bud formation
GO:0060221	retinal rod cell differentiation
GO:0060350	endochondral bone morphogenesis
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0060512	prostate gland morphogenesis
GO:0060517	epithelial cell proliferation involved in prostatic bud elongation
GO:0060729	intestinal epithelial structure maintenance
GO:0060784	regulation of cell proliferation involved in tissue homeostasis
GO:0061036	positive regulation of cartilage development
GO:0061046	regulation of branching involved in lung morphogenesis
GO:0061138	morphogenesis of a branching epithelium
GO:0070168	negative regulation of biomineral tissue development
GO:0070371	ERK1 and ERK2 cascade
GO:0071260	cellular response to mechanical stimulus
GO:0071300	cellular response to retinoic acid
GO:0071347	cellular response to interleukin-1
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071504	cellular response to heparin
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071599	otic vesicle development
GO:0072034	renal vesicle induction
GO:0072170	metanephric tubule development
GO:0072189	ureter development
GO:0072190	ureter urothelium development
GO:0072193	ureter smooth muscle cell differentiation
GO:0072197	ureter morphogenesis
GO:0072289	metanephric nephron tubule formation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090103	cochlea morphogenesis
GO:0090184	positive regulation of kidney development
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:1901203	positive regulation of extracellular matrix assembly
GO:2000020	positive regulation of male gonad development
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis
GO:2000741	positive regulation of mesenchymal stem cell differentiation
GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis
GO:2001054	negative regulation of mesenchymal cell apoptotic process