InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lime1

Summary

InnateDB Protein

IDBP-214092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lime1

Protein Name

Lck interacting transmembrane adaptor 1

Synonyms

2810038K19Rik; LIME;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045010

InnateDB Gene

IDBG-488854 (Lime1)

Protein Structure

UniProt Annotation

Function

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269PubMed:14610044, ECO:0000269PubMed:16249387}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14610044}; Single-pass type III membrane protein {ECO:0000269PubMed:14610044}. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.

Disease Associations

Tissue Specificity

Expressed in spleen and lung. Present in primary B-cells and peripheral T-cells (at protein level). {ECO:0000269PubMed:14610044, ECO:0000269PubMed:16249387}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043405	regulation of MAP kinase activity
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0051279	regulation of release of sequestered calcium ion into cytosol