Version 5.4
Mus musculus Protein: Llgl2
Summary
InnateDB Protein IDBP-214362.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Llgl2
Protein Name lethal giant larvae homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099321
InnateDB Gene IDBG-214360 (Llgl2)
Protein Structure
UniProt Annotation
Function Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006887 exocytosis
GO:0007049 cell cycle
GO:0032878 regulation of establishment or maintenance of cell polarity
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1918843
InterPro IPR000664 Lethal(2) giant larvae protein
IPR001680 WD40 repeat
IPR013577 Lethal giant larvae homologue 2
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PF08366
PRINTS PR00962
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TJ91
PhosphoSite PhosphoSite-Q3TJ91
TrEMBL Q8BVC8
UniProt Splice Variant
Entrez Gene 217325
UniGene Mm.290450
RefSeq NP_663413
MGI ID
MGI Symbol Llgl2
OMIM
CCDS CCDS25649
HPRD
IMGT
EMBL AK078901 AK167536 AL645647 AL645852 AY033650 BC037226
GenPept AAH37226 AAK52346 BAC37449 BAE39604 CAM21985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca