InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acox1

Summary

InnateDB Protein

IDBP-214425.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acox1

Protein Name

acyl-Coenzyme A oxidase 1, palmitoyl

Synonyms

Acox; AOX; D130055E20Rik; Paox;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072717

InnateDB Gene

IDBG-214419 (Acox1)

Protein Structure

UniProt Annotation

Function

Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels of isoform 1 are found in liver and kidney while highest levels of isoform 2 are found in white adipose tissue. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 is expressed at higher levels in brain, heart, lung, muscle, white adipose tissue and testis. {ECO:0000269PubMed:20195242}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0005504	fatty acid binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006693	prostaglandin metabolic process
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0016559	peroxisome fission
GO:0019395	fatty acid oxidation
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0055088	lipid homeostasis
GO:0055114	oxidation-reduction process
GO:2000189	positive regulation of cholesterol homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane

Protein Structure and Domains

PDB ID

MGI:1330812

InterPro

IPR002655 Acyl-CoA oxidase, C-terminal
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR012258 Acyl-CoA oxidase

PFAM

PF01756
PF02770
PF00441

PRINTS

PIRSF

PIRSF000168

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R0H0