Version 5.4
Homo sapiens Protein: TMPRSS11E
Summary
InnateDB Protein IDBP-21443.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS11E
Protein Name transmembrane protease, serine 11E
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000307519
InnateDB Gene IDBG-21441 (TMPRSS11E)
Protein Structure
UniProt Annotation
Function Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Transmembrane protease serine 11E catalytic chain: Secreted {ECO:0000250}. Note=Activated by cleavage and secreted. {ECO:0000250}.
Disease Associations
Tissue Specificity Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis. {ECO:0000269PubMed:11161383}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0050890 cognition
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000082 SEA domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017329 Peptidase S1A, HAT/DESC1
PFAM PF01390
PF00089
PF09342
PRINTS PR00722
PIRSF PIRSF037941
SMART SM00200
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UL52
PhosphoSite PhosphoSite-Q9UL52
TrEMBL Q4W5P3
UniProt Splice Variant
Entrez Gene 28983
UniGene Hs.201877
RefSeq NP_054777
HUGO HGNC:24465
OMIM 610399
CCDS CCDS33993
HPRD 09912
IMGT
EMBL AC019173 AC079749 AC140484 AF064819 AY359017 BC113412 BC113414
GenPept AAF04328 AAI13413 AAI13415 AAQ89376 AAY40995

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca