Version 5.4
Mus musculus Protein: Galr2
Summary
InnateDB Protein IDBP-214440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Galr2
Protein Name galanin receptor 2
Synonyms mGalR;
Species Mus musculus
Ensembl Protein ENSMUSP00000054062
InnateDB Gene IDBG-214438 (Galr2)
Protein Structure
UniProt Annotation
Function Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004966 galanin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0031175 neuron projection development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1337018
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000405 Galanin receptor family
IPR003907 Galanin receptor 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
PFAM PF00001
PF10320
PF10323
PF10324
PRINTS PR00237
PR00663
PR01419
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88854
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14428
UniGene Mm.57149
RefSeq NP_034384
MGI ID
MGI Symbol Galr2
OMIM
CCDS CCDS25663
HPRD
IMGT
EMBL AF042784 AF077375 AL645861 BC116980 BC116982 CH466558
GenPept AAC36589 AAC95468 AAI16981 AAI16983 CAM16797 EDL34569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca