InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mgat5b

Summary

InnateDB Protein

IDBP-214544.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgat5b

Protein Name

mannoside acetylglucosaminyltransferase 5, isoenzyme B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099316

InnateDB Gene

IDBG-214540 (Mgat5b)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:16413118}; Single-pass type II membrane protein {ECO:0000269PubMed:16413118}.

Disease Associations

Tissue Specificity

Present in brain (at protein level). Predominantly expressed in cerebrum and cerebellum. {ECO:0000269PubMed:16413118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
GO:0046872	metal ion binding