InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde6g

Summary

InnateDB Protein

IDBP-214808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde6g

Protein Name

phosphodiesterase 6G, cGMP-specific, rod, gamma

Synonyms

p3AT; Pdeg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026452

InnateDB Gene

IDBG-214806 (Pde6g)

Protein Structure

UniProt Annotation

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Subcellular Localization

Disease Associations

Note=Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0030553	cGMP binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0050896	response to stimulus