Version 5.4
Mus musculus Protein: Anapc11
Summary
InnateDB Protein IDBP-214850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anapc11
Protein Name anaphase promoting complex subunit 11
Synonyms 1110011I19Rik; R75218;
Species Mus musculus
Ensembl Protein ENSMUSP00000026128
InnateDB Gene IDBG-214848 (Anapc11)
Protein Structure
UniProt Annotation
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913406
InterPro IPR001841 Zinc finger, RING-type
PFAM PF13639
PF14634
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CPX9
PhosphoSite PhosphoSite-Q9CPX9
TrEMBL
UniProt Splice Variant
Entrez Gene 66156
UniGene Mm.21645
RefSeq NP_079665
MGI ID
MGI Symbol Anapc11
OMIM
CCDS CCDS25745
HPRD
IMGT
EMBL AK003244 AK003612 AK003684 AK045408 AK136358 BC023039
GenPept AAH23039 BAB22663 BAB22890 BAB22937 BAC32348 BAE22944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca