InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pycr1

Summary

InnateDB Protein

IDBP-214867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pycr1

Protein Name

pyrroline-5-carboxylate reductase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026133

InnateDB Gene

IDBG-214865 (Pycr1)

Protein Structure

UniProt Annotation

Function

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Highly expressed in osteoblasts and skin. {ECO:0000269PubMed:19648921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004735	pyrroline-5-carboxylate reductase activity
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

Biological Process

GO:0006561	proline biosynthetic process
GO:0034599	cellular response to oxidative stress
GO:0046168	glycerol-3-phosphate catabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:2384795

InterPro

IPR000304 Pyrroline-5-carboxylate reductase
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF01210
PF03807

PRINTS

PIRSF

PIRSF000193

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q922W5