InnateDB Protein
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IDBP-21502.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UGT2B15
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Protein Name
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UDP glucuronosyltransferase 2 family, polypeptide B15
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Synonyms
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HLUG4; UDPGT 2B8; UDPGT2B15; UDPGTH3; UGT2B8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000341045
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InnateDB Gene
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IDBG-21500 (UGT2B15)
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Protein Structure
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Function |
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
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Subcellular Localization |
Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in many tissues. Present in liver, prostate and testis. {ECO:0000269PubMed:8399210}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
0
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015020
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glucuronosyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0030246
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carbohydrate binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002213
UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235
Glycosyl transferase, family 28, C-terminal
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PFAM |
PF00201
PF04101
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P54855
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PhosphoSite |
PhosphoSite-P54855
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7366
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UniGene |
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RefSeq |
NP_001067
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HUGO |
HGNC:12546
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OMIM |
600069
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CCDS |
CCDS3524
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HPRD |
07192
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IMGT |
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EMBL |
AC019173
AC147055
AF180322
AF548389
AK289419
CH471057
U06641
U08854
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GenPept |
AAA83406
AAC50077
AAD55093
AAN40695
BAF82108
EAX05574
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