InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: mt-Nd6

Summary

InnateDB Protein

IDBP-215050.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

mt-Nd6

Protein Name

mitochondrially encoded NADH dehydrogenase 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081002

InnateDB Gene

IDBG-215048 (mt-Nd6)

Protein Structure

UniProt Annotation

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0070469	respiratory chain

Protein Structure and Domains

PDB ID

MGI:102495

InterPro

IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6

PFAM

PF00499

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AB042523 AB042524 AB042809 AB049357 AJ489607 AJ512208 AK138272 AK140300 AP013030 AP013031 AP013054 AP014540 AP014541 AY172335 AY339599 AY466499 AY533105 AY533106 AY533107 AY533108 AY999076 DQ106412 DQ106413 EF108330 EF108331 EF108332 EF108333 EF108334 EF108335 EF108336 EF108337 EF108338 EF108339 EF108340 EF108341 EU312160 EU315229 EU450583 FJ803909 HQ586004 HQ675026 HQ675027 HQ675028 HQ675029 HQ675030 HQ675031 HQ877407 J01420 JF286601 JQ003190 V00711

GenPept

AAB48655 AAN85133 AAP89034 AAR21206 AAS01437 AAS01450 AAS01463 AAS01476 AAX83023 AAY96700 AAY96713 ABK79104 ABK79117 ABK79130 ABK79143 ABK79156 ABK79169 ABK79182 ABK79195 ABK79208 ABK79221 ABK79234 ABK79247 ABX79713 ABX79752 ACA01535 ACN91106 ADR03167 ADW83077 ADZ23177 AEN03380 AEN03393 AEN03406 AEN03419 AEN03432 AEN03445 AEV56608 BAA95651 BAA95664 BAA95806 BAB13812 BAE23604 BAE24323 BAM93594 BAM93607 BAN16603 BAO42861 BAO42874 CAA24089 CAD33918 CAD54443

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca