InnateDB Protein
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IDBP-21872.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UGT2B4
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Protein Name
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UDP glucuronosyltransferase 2 family, polypeptide B4
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Synonyms
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HLUG25; UDPGT2B4; UDPGTh-1; UDPGTH1; UGT2B11;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305221
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InnateDB Gene
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IDBG-21870 (UGT2B4)
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Protein Structure
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Function |
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
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Subcellular Localization |
Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015020
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glucuronosyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0030246
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carbohydrate binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002213
UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235
Glycosyl transferase, family 28, C-terminal
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PFAM |
PF00201
PF04101
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P06133
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PhosphoSite |
PhosphoSite-P06133
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TrEMBL |
D6RGY0
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UniProt Splice Variant |
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Entrez Gene |
7363
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UniGene |
Hs.737169
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RefSeq |
NP_066962
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HUGO |
HGNC:12553
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OMIM |
600067
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CCDS |
CCDS43234
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HPRD |
02507
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IMGT |
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EMBL |
AC093829
AC108078
AF064200
AF081793
AF135416
AJ005162
AK292748
BC026264
DQ520733
Y00317
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GenPept |
AAC32272
AAC95002
AAF78145
AAH26264
ABF47107
BAF85437
CAA06396
CAA68415
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