InnateDB Protein
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IDBP-21914.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GTF3C1
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Protein Name
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general transcription factor IIIC, polypeptide 1, alpha 220kDa
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Synonyms
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TFIIIC; TFIIIC220; TFIIICalpha;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348510
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InnateDB Gene
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IDBG-21912 (GTF3C1)
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Protein Structure
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Function |
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
66
[view]
|
Protein-Protein |
66
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007309
B-block binding subunit of TFIIIC
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PFAM |
PF04182
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q12789
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PhosphoSite |
PhosphoSite-Q12789
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TrEMBL |
Q7Z7H4
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UniProt Splice Variant |
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Entrez Gene |
2975
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UniGene |
Hs.707935
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RefSeq |
NP_001511
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HUGO |
HGNC:4664
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OMIM |
603246
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CCDS |
CCDS32414
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HPRD |
07540
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IMGT |
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EMBL |
AC002303
AC002551
AC025275
BC044857
BC052642
BC137229
U02619
U06485
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GenPept |
AAA17985
AAA85638
AAB67637
AAC05811
AAH44857
AAH52642
AAI37230
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