InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIP10

Summary

InnateDB Protein

IDBP-21943.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIP10

Protein Name

thyroid hormone receptor interactor 10

Synonyms

CIP4; HSTP; STOT; STP; TRIP-10;

Species

Homo sapiens

Ensembl Protein

ENSP00000320493

InnateDB Gene

IDBG-21941 (TRIP10)

Protein Structure

UniProt Annotation

Function

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269PubMed:11069762, ECO:0000269PubMed:16318909, ECO:0000269PubMed:16326391}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F- actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.Isoform 5: Cytoplasm, perinuclear region.

Disease Associations

Tissue Specificity

Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. {ECO:0000269PubMed:11294612, ECO:0000269PubMed:12054674, ECO:0000269PubMed:12456510, ECO:0000269PubMed:12604778, ECO:0000269PubMed:9210375}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding

Biological Process

GO:0006897	endocytosis
GO:0007154	cell communication
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0030036	actin cytoskeleton organization
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0042995	cell projection
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome