InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSN2

Summary

InnateDB Protein

IDBP-22066.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSN2

Protein Name

casein beta

Synonyms

CASB;

Species

Homo sapiens

Ensembl Protein

ENSP00000341030

InnateDB Gene

IDBG-22064 (CSN2)

Protein Structure

UniProt Annotation

Function

Important role in determination of the surface properties of the casein micelles.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Mammary gland specific. Secreted in milk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005215	transporter activity
GO:0005509	calcium ion binding

Biological Process

GO:0006810	transport
GO:0006816	calcium ion transport
GO:0007595	lactation
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001588 Casein, alpha/beta
IPR016345 Casein, beta

PFAM

PF00363

PRINTS

PIRSF

PIRSF002372

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05814

PhosphoSite

PhosphoSite-P05814

TrEMBL

W5RWE1

UniProt Splice Variant

Entrez Gene

1447

UniGene

Hs.2242

RefSeq

NP_001882

HUGO

HGNC:2447

OMIM

115460

CCDS

CCDS3532

HPRD

00281

IMGT

EMBL

AF027807 BC069554 BC096194 BC096195 BC096196 BC096197 CH471057 KF751868 X13766 X17070 X55739

GenPept

AAC82978 AAH69554 AAH96194 AAH96195 AAH96196 AAH96197 AHG94922 CAA32017 CAA34916 CAA39270 EAX05602