Version 5.4
Mus musculus Protein: Cacng7
Summary
InnateDB Protein IDBP-221927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacng7
Protein Name calcium channel, voltage-dependent, gamma subunit 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000090567
InnateDB Gene IDBG-221925 (Cacng7)
Protein Structure
UniProt Annotation
Function Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0016021 integral component of membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Protein Structure and Domains
PDB ID MGI:1932374
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR008368 Voltage-dependent calcium channel, gamma subunit
IPR008371 Voltage-dependent calcium channel, gamma-7 subunit
PFAM PF00822
PF13903
PRINTS PR01792
PR01795
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62956
PhosphoSite PhosphoSite-P62956
TrEMBL B9EJ14
UniProt Splice Variant
Entrez Gene 81904
UniGene Mm.214994
RefSeq NP_573452
MGI ID
MGI Symbol Cacng7
OMIM
CCDS CCDS39725
HPRD
IMGT
EMBL AF361349 AF458899 BC141277 CH466627
GenPept AAI41278 AAL50044 AAM00596 EDL31176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca