InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GART

Summary

InnateDB Protein

IDBP-2222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GART

Protein Name

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Synonyms

AIRS; GARS; GARTF; PAIS; PGFT; PRGS;

Species

Homo sapiens

Ensembl Protein

ENSP00000371253

InnateDB Gene

IDBG-2218 (GART)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004637	phosphoribosylamine-glycine ligase activity
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644	phosphoribosylglycinamide formyltransferase activity
GO:0005524	ATP binding
GO:0008168	methyltransferase activity
GO:0016742	hydroxymethyl-, formyl- and related transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0003360	brainstem development
GO:0006144	purine nucleobase metabolic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0006544	glycine metabolic process
GO:0009058	biosynthetic process
GO:0009113	purine nucleobase biosynthetic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0010033	response to organic substance
GO:0010035	response to inorganic substance
GO:0021549	cerebellum development
GO:0021987	cerebral cortex development
GO:0032259	methylation
GO:0044281	small molecule metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000115 Phosphoribosylglycinamide synthetase
IPR000728 AIR synthase related protein, N-terminal domain
IPR002376 Formyl transferase, N-terminal
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR004607 Phosphoribosylglycinamide formyltransferase
IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR010918 AIR synthase-related protein, C-terminal domain
IPR011054 Rudiment single hybrid motif
IPR011761 ATP-grasp fold
IPR016185 Pre-ATP-grasp domain
IPR016188 PurM, N-terminal-like
IPR020560 Phosphoribosylglycinamide synthetase, C-domain
IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
IPR020562 Phosphoribosylglycinamide synthetase, N-terminal

PFAM