InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP1A1

Summary

InnateDB Protein

IDBP-22479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP1A1

Protein Name

cytochrome P450, family 1, subfamily A, polypeptide 1

Synonyms

AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX;

Species

Homo sapiens

Ensembl Protein

ENSP00000369050

InnateDB Gene

IDBG-22475 (CYP1A1)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Lung, lymphocytes and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016711	flavonoid 3'-monooxygenase activity
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0032451	demethylase activity
GO:0070330	aromatase activity
GO:0070576	vitamin D 24-hydroxylase activity

Biological Process

GO:0001666	response to hypoxia
GO:0001889	liver development
GO:0006778	porphyrin-containing compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007568	aging
GO:0008283	cell proliferation
GO:0009308	amine metabolic process
GO:0009404	toxin metabolic process
GO:0009611	response to wounding
GO:0009615	response to virus
GO:0009624	response to nematode
GO:0009635	response to herbicide
GO:0009636	response to toxic substance
GO:0009792	embryo development ending in birth or egg hatching
GO:0009804	coumarin metabolic process
GO:0009812	flavonoid metabolic process
GO:0010033	response to organic substance
GO:0010041	response to iron(III) ion
GO:0014070	response to organic cyclic compound
GO:0017143	insecticide metabolic process
GO:0017144	drug metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0019341	dibenzo-p-dioxin catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0032502	developmental process
GO:0033189	response to vitamin A
GO:0035902	response to immobilization stress
GO:0042359	vitamin D metabolic process
GO:0042493	response to drug
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0043010	camera-type eye development
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046483	heterocycle metabolic process
GO:0046677	response to antibiotic
GO:0046685	response to arsenic-containing substance
GO:0048565	digestive tract development
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process
GO:0060137	maternal process involved in parturition
GO:0070365	hepatocyte differentiation
GO:0070988	demethylation
GO:0071407	cellular response to organic cyclic compound
GO:0097267	omega-hydroxylase P450 pathway
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008066 Cytochrome P450, E-class, group I, CYP1

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01683

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P04798