InnateDB Protein
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IDBP-227956.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PQLC2
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Protein Name
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PQ loop repeat containing 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000383395
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InnateDB Gene
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IDBG-92555 (PQLC2)
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Protein Structure
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Function |
Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. {ECO:0000269PubMed:22822152, ECO:0000269PubMed:23169667}.
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Subcellular Localization |
Lysosome membrane {ECO:0000269PubMed:22822152}; Multi-pass membrane protein {ECO:0000269PubMed:22822152}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0015181
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arginine transmembrane transporter activity
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GO:0015189
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L-lysine transmembrane transporter activity
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GO:0015326
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cationic amino acid transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006603
PQ-loop repeat
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PFAM |
PF04193
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PRINTS |
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PIRSF |
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SMART |
SM00679
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZP29
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PhosphoSite |
PhosphoSite-Q6ZP29
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TrEMBL |
A0A024RAA1
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UniProt Splice Variant |
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Entrez Gene |
54896
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UniGene |
Hs.647620
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RefSeq |
NP_001274460
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HUGO |
HGNC:26001
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OMIM |
614760
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CCDS |
CCDS30618
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HPRD |
17896
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IMGT |
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EMBL |
AK000327
AK125580
AK130171
AK130175
AK172745
AL035413
BC015324
CH471134
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GenPept |
AAH15324
BAA91088
BAC85296
BAC85298
BAD18732
BAG54217
CAI22229
CAM12847
EAW94883
EAW94886
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