InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GP1BB

Summary

InnateDB Protein

IDBP-228022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GP1BB

Protein Name

glycoprotein Ib (platelet), beta polypeptide

Synonyms

BDPLT1; BS; CD42C; GPIBB;

Species

Homo sapiens

Ensembl Protein

ENSP00000383382

InnateDB Gene

IDBG-121855 (GP1BB)

Protein Structure

UniProt Annotation

Function

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Bernard-Soulier syndrome (BSS) [MIM:231200]: A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption. {ECO:0000269PubMed:9116284}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in heart and brain. {ECO:0000269PubMed:8200976}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0030168	platelet activation