InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABPA

Summary

InnateDB Protein

IDBP-229089.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABPA

Protein Name

GA binding protein transcription factor, alpha subunit 60kDa

Synonyms

E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A; RCH04A07;

Species

Homo sapiens

Ensembl Protein

ENSP00000382948

InnateDB Gene

IDBG-1089 (GABPA)

Protein Structure

UniProt Annotation

Function

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	34 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000418 Ets domain
IPR003118 Pointed domain
IPR013761 Sterile alpha motif/pointed domain
IPR016312 Transcription factor, GA-binding, alpha subunit
IPR024668 GA-binding protein alpha subunit, N-terminal
IPR029071 Ubiquitin-related domain

PFAM

PF00178
PF02198
PF11620

PRINTS

PR00454

PIRSF

PIRSF001703

SMART

SM00413
SM00251

TIGRFAMs

Post-translational Modifications

Modification

Cross-References