InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C12orf39

Summary

InnateDB Protein

IDBP-22942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C12orf39

Protein Name

chromosome 12 open reading frame 39

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256969

InnateDB Gene

IDBG-22940 (C12orf39)

Protein Structure

UniProt Annotation

Function

Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}.Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic- like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231). {ECO:0000250, ECO:0000269PubMed:17284679, ECO:0000269PubMed:24517231}.Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.

Disease Associations

Tissue Specificity

Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus. {ECO:0000269PubMed:17284679, ECO:0000269PubMed:19132080, ECO:0000269PubMed:19193193, ECO:0000269PubMed:23080164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005184	neuropeptide hormone activity
GO:0031765	type 2 galanin receptor binding
GO:0031766	type 3 galanin receptor binding

Biological Process

GO:0003084	positive regulation of systemic arterial blood pressure
GO:0010459	negative regulation of heart rate
GO:0032099	negative regulation of appetite
GO:0035814	negative regulation of renal sodium excretion
GO:0044539	long-chain fatty acid import
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051930	regulation of sensory perception of pain