InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RUNX3

Summary

InnateDB Protein

IDBP-229486.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUNX3

Protein Name

runt-related transcription factor 3

Synonyms

AML2; CBFA3; PEBP2aC;

Species

Homo sapiens

Ensembl Protein

ENSP00000382800

InnateDB Gene

IDBG-94257 (RUNX3)

Protein Structure

UniProt Annotation

Function

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00399, ECO:0000269PubMed:20100835}. Cytoplasm {ECO:0000269PubMed:20100835}. Note=The tyrosine phosphorylated form localizes to the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	46 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002062	chondrocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007411	axon guidance
GO:0031069	hair follicle morphogenesis
GO:0031175	neuron projection development
GO:0032609	interferon-gamma production
GO:0045087	innate immune response (InnateDB)
GO:0045786	negative regulation of cell cycle
GO:0048469	cell maturation
GO:0048935	peripheral nervous system neuron development
GO:0050680	negative regulation of epithelial cell proliferation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
IPR013711 Runx, C-terminal domain
IPR016554 Runt-related transcription factor RUNX

PFAM

PF00853
PF08504

PRINTS

PR00967

PIRSF

PIRSF009374

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt