Version 5.4
Homo sapiens Protein: RPP25
Summary
InnateDB Protein IDBP-22975.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPP25
Protein Name ribonuclease P/MRP 25kDa subunit
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000317691
InnateDB Gene IDBG-22973 (RPP25)
Protein Structure
UniProt Annotation
Function Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA.
Subcellular Localization Nucleus {ECO:0000269PubMed:12003489}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008033 tRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002775 DNA/RNA-binding protein Alba-like
PFAM PF01918
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BUL9
PhosphoSite PhosphoSite-Q9BUL9
TrEMBL
UniProt Splice Variant
Entrez Gene 54913
UniGene Hs.8562
RefSeq NP_060263
HUGO HGNC:30361
OMIM
CCDS CCDS10274
HPRD 15276
IMGT
EMBL AK000381 AY034074 BC002497 BC007270 CH471136
GenPept AAH02497 AAH07270 AAK54443 BAA91128 EAW99285 EAW99286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca