Version 5.4
Homo sapiens Protein: XAB2
Summary
InnateDB Protein IDBP-23048.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XAB2
Protein Name XPA binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351137
InnateDB Gene IDBG-23046 (XAB2)
Protein Structure
UniProt Annotation
Function Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. {ECO:0000269PubMed:10944529}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Detected in the splicing complex carrying pre-mRNA. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001824 blastocyst development
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006396 RNA processing
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR003107 HAT (Half-A-TPR) repeat
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF02184
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00386
SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCS7
PhosphoSite PhosphoSite-Q9HCS7
TrEMBL Q68CN2
UniProt Splice Variant
Entrez Gene 56949
UniGene Hs.9822
RefSeq NP_064581
HUGO HGNC:14089
OMIM 610850
CCDS CCDS32892
HPRD 18306
IMGT
EMBL AB026111 AB033003 AC008763 AF226051 AF258567 AF547265 AK074035 BC007208 BC008778 CR749864
GenPept AAF86951 AAG23770 AAH07208 AAH08778 AAN17847 BAA86491 BAB15807 BAB84861 CAH18708

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca