InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGB1

Summary

InnateDB Protein

IDBP-230495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGB1

Protein Name

high mobility group box 1

Synonyms

HMG1; HMG3; SBP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000382417

InnateDB Gene

IDBG-21100 (HMGB1)

Protein Structure

UniProt Annotation

Function

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	76 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0042056	chemoattractant activity
GO:0044822	poly(A) RNA binding
GO:0050786	RAGE receptor binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001773	myeloid dendritic cell activation
GO:0002407	dendritic cell chemotaxis
GO:0002437	inflammatory response to antigenic stimulus
GO:0006265	DNA topological change
GO:0006288	base-excision repair, DNA ligation
GO:0006309	apoptotic DNA fragmentation
GO:0006310	DNA recombination
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0031175	neuron projection development
GO:0033151	V(D)J recombination
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050918	positive chemotaxis
GO:0051103	DNA ligation involved in DNA repair

Cellular Component

GO:0000793	condensed chromosome
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0009986	cell surface
GO:0017053	transcriptional repressor complex