InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC16A11

Summary

InnateDB Protein

IDBP-23094.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC16A11

Protein Name

solute carrier family 16, member 11 (monocarboxylic acid transporter 11)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310490

InnateDB Gene

IDBG-23092 (SLC16A11)

Protein Structure

UniProt Annotation

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids. {ECO:0000250, ECO:0000269PubMed:24390345}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:24390345}; Multi-pass membrane protein {ECO:0000269PubMed:24390345}.

Disease Associations

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345). {ECO:0000269PubMed:24390345}.

Tissue Specificity

Expressed in liver, salivary gland and thyroid. {ECO:0000269PubMed:24390345}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity

Biological Process

GO:0006629	lipid metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NCK7

PhosphoSite