InnateDB Protein
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IDBP-23094.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC16A11
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Protein Name
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solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310490
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InnateDB Gene
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IDBG-23092 (SLC16A11)
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Protein Structure
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Function |
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids. {ECO:0000250, ECO:0000269PubMed:24390345}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:24390345}; Multi-pass membrane protein {ECO:0000269PubMed:24390345}.
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Disease Associations |
Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345). {ECO:0000269PubMed:24390345}.
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Tissue Specificity |
Expressed in liver, salivary gland and thyroid. {ECO:0000269PubMed:24390345}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NCK7
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PhosphoSite |
PhosphoSite-Q8NCK7
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TrEMBL |
I3L431
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UniProt Splice Variant |
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Entrez Gene |
162515
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UniGene |
Hs.336564
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RefSeq |
NP_699188
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HUGO |
HGNC:23093
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OMIM |
615765
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CCDS |
CCDS11086
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HPRD |
11567
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IMGT |
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EMBL |
AC040977
AK074674
BC093860
BC093886
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GenPept |
AAH93860
AAH93886
BAC11128
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