Version 5.4
Homo sapiens Protein: AIFM3
Summary
InnateDB Protein IDBP-231247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIFM3
Protein Name apoptosis-inducing factor, mitochondrion-associated, 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000382120
InnateDB Gene IDBG-1846 (AIFM3)
Protein Structure
UniProt Annotation
Function Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. {ECO:0000269PubMed:15764604}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:15764604}. Note=Does not translocate to the nucleus upon induction of apoptosis.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level). {ECO:0000269PubMed:15764604}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR017941 Rieske [2Fe-2S] iron-sulphur domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
PFAM PF00070
PF00355
PF07992
PRINTS PR00469
PR00368
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NN9
PhosphoSite PhosphoSite-Q96NN9
TrEMBL C9K029
UniProt Splice Variant
Entrez Gene 150209
UniGene Hs.739104
RefSeq NP_653305
HUGO HGNC:26398
OMIM
CCDS CCDS13786
HPRD 08085
IMGT
EMBL AC002470 AK055035 AK094844 BC032485 CH471176 CR456342
GenPept AAH32485 BAB70841 BAC04434 CAG30228 EAX02924 EAX02925 EAX02926 EAX02927 EAX02930 EAX02931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca