InnateDB Protein
|
IDBP-231375.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CTNND1
|
Protein Name
|
catenin (cadherin-associated protein), delta 1
|
Synonyms
|
CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000382004
|
InnateDB Gene
|
IDBG-47085 (CTNND1)
|
Protein Structure
|
|
Function |
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269PubMed:17344476, ECO:0000269PubMed:20371349}.
|
Subcellular Localization |
Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus. {ECO:0000250}.Isoform 1A: Nucleus.Isoform 2A: Nucleus.Isoform 3A: Nucleus.
|
Disease Associations |
|
Tissue Specificity |
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. {ECO:0000269PubMed:11896187, ECO:0000269PubMed:14699141}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
73
[view]
|
Protein-Protein |
73
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
16 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000225
Armadillo
IPR016024
Armadillo-type fold
|
PFAM |
PF00514
|
PRINTS |
|
PIRSF |
|
SMART |
SM00185
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O60716
|
PhosphoSite |
PhosphoSite-O60716
|
TrEMBL |
E9PKY0
|
UniProt Splice Variant |
|
Entrez Gene |
1500
|
UniGene |
Hs.166011
|
RefSeq |
NP_001078927
|
HUGO |
HGNC:2515
|
OMIM |
601045
|
CCDS |
CCDS44604
|
HPRD |
03026
|
IMGT |
|
EMBL |
AB002382
AF062317
AF062318
AF062319
AF062320
AF062321
AF062322
AF062323
AF062324
AF062325
AF062326
AF062327
AF062328
AF062329
AF062330
AF062331
AF062332
AF062333
AF062334
AF062335
AF062336
AF062337
AF062338
AF062339
AF062340
AF062341
AF062342
AF062343
AF062344
AK292554
AP001931
AY505564
BC075795
|
GenPept |
AAC39802
AAC39803
AAC39804
AAC39805
AAC39806
AAC39807
AAC39808
AAC39809
AAC39810
AAC39811
AAC39812
AAC39813
AAC39814
AAC39815
AAC39816
AAC39817
AAC39818
AAC39819
AAC39820
AAC39821
AAC39822
AAC39823
AAC39824
AAC39825
AAC39826
AAC39827
AAC39828
AAC39829
AAH75795
AAR84236
BAA20838
BAF85243
|
|
|