InnateDB Protein
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IDBP-231663.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPRD1A
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Protein Name
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regulation of nuclear pre-mRNA domain containing 1A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381984
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InnateDB Gene
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IDBG-2531 (RPRD1A)
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Protein Structure
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Function |
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269PubMed:22231121}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0070940
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dephosphorylation of RNA polymerase II C-terminal domain
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Cellular Component |
GO:0016591
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DNA-directed RNA polymerase II, holoenzyme
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PDB ID |
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InterPro |
IPR006569
CID domain
IPR006903
RNA polymerase II-binding domain
IPR008942
ENTH/VHS
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PFAM |
PF04818
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PRINTS |
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PIRSF |
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SMART |
SM00582
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TIGRFAMs |
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Modification |
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SwissProt |
Q96P16
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PhosphoSite |
PhosphoSite-Q96P16
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TrEMBL |
K7ER50
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UniProt Splice Variant |
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Entrez Gene |
55197
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UniGene |
Hs.645628
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RefSeq |
NP_060640
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HUGO |
HGNC:25560
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OMIM |
610347
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CCDS |
CCDS11917
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HPRD |
10134
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IMGT |
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EMBL |
AC091060
AF419845
AK001518
AK292907
AK314569
BC000225
BC010136
CH471088
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GenPept |
AAH00225
AAH10136
AAL15972
BAA91736
BAF85596
BAG37150
EAX01365
EAX01366
EAX01367
EAX01368
EAX01369
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