Version 5.4
Homo sapiens Protein: MGARP
Summary
InnateDB Protein IDBP-231811.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGARP
Protein Name chromosome 4 open reading frame 49
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381928
InnateDB Gene IDBG-38342 (MGARP)
Protein Structure
UniProt Annotation
Function Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269PubMed:16565373, ECO:0000269PubMed:21447634}. Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid- producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells. {ECO:0000269PubMed:12036975, ECO:0000269PubMed:12770732, ECO:0000269PubMed:16565373, ECO:0000269PubMed:19325000, ECO:0000269PubMed:19528298}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0008089 anterograde axon cargo transport
GO:0008090 retrograde axon cargo transport
GO:0010822 positive regulation of mitochondrion organization
GO:0019896 axon transport of mitochondrion
GO:0071383 cellular response to steroid hormone stimulus
GO:0071456 cellular response to hypoxia
GO:0097211 cellular response to gonadotropin-releasing hormone
Cellular Component
GO:0005739 mitochondrion
GO:0031307 integral component of mitochondrial outer membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDB4
PhosphoSite PhosphoSite-Q8TDB4
TrEMBL
UniProt Splice Variant
Entrez Gene 84709
UniGene Hs.710036
RefSeq NP_116012
HUGO HGNC:29969
OMIM
CCDS CCDS43269
HPRD 17805
IMGT
EMBL AF329088 AF484960 BC104173 BC104174 CH471056
GenPept AAG59896 AAI04174 AAI04175 AAM09685 EAX05122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca