InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAMTS3

Summary

InnateDB Protein

IDBP-23191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS3

Protein Name

ADAM metallopeptidase with thrombospondin type 1 motif, 3

Synonyms

ADAMTS-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000286657

InnateDB Gene

IDBG-23189 (ADAMTS3)

Protein Structure

UniProt Annotation

Function

Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in cartilage and skin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0010573	vascular endothelial growth factor production
GO:0016485	protein processing
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0032964	collagen biosynthetic process
GO:0043206	extracellular fibril organization
GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR010294 ADAM-TS Spacer 1
IPR010909 PLAC
IPR013273 Peptidase M12B, ADAM-TS

PFAM

PF00090
PF01421
PF01562
PF05986
PF08686

PRINTS

PR01857

PIRSF

SMART

SM00209

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt